"Baylor Genetics"[submitter] AND "MSH3"[gene] - ClinVar - NCBI

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	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 2676745	NM_002439.5(MSH3):c.4T>A (p.Ser2Thr)	DHFR, MSH3 (S2T)	Single nucleotide variant (5 prime UTR variant +2 more)	Endometrial carcinoma	GUncertain significance
Select item 854380	NM_002439.5(MSH3):c.7C>T (p.Arg3Cys)	DHFR, MSH3 (R3C)	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 940655	NM_002439.5(MSH3):c.14del (p.Lys5fs)	DHFR, MSH3 (K5fs)	Deletion (5 prime UTR variant +2 more)	Endometrial carcinoma +3 more	GPathogenic/Likely pathogenic
Select item 2676774	NM_002439.5(MSH3):c.15del (p.Lys5fs)	DHFR, MSH3 (K5fs)	Deletion (5 prime UTR variant +2 more)	Endometrial carcinoma	GLikely pathogenic
Select item 650237	NM_000791.4(DHFR):c.-254G>A	DHFR, MSH3 (P6S)	Single nucleotide variant (5 prime UTR variant +2 more)	not provided +4 more	GUncertain significance
Select item 2676736	NM_002439.5(MSH3):c.23C>T (p.Ser8Leu)	DHFR, MSH3 (S8L)	Single nucleotide variant (5 prime UTR variant +2 more)	Endometrial carcinoma +1 more	GUncertain significance
Select item 940522	NM_000791.4(DHFR):c.-264C>A	DHFR, MSH3 (G9V)	Single nucleotide variant (5 prime UTR variant +2 more)	not specified +2 more	GUncertain significance
Select item 2676764	NM_002439.5(MSH3):c.53C>T (p.Pro18Leu)	DHFR, MSH3 (P18L)	Single nucleotide variant (missense variant +2 more)	Endometrial carcinoma	GUncertain significance
Select item 2105153	NM_002439.5(MSH3):c.55G>C (p.Ala19Pro)	DHFR, MSH3 (A19P)	Single nucleotide variant (5 prime UTR variant +2 more)	not provided +1 more	GUncertain significance
Select item 663065	NM_002439.5(MSH3):c.59G>A (p.Arg20Lys)	DHFR, MSH3 (R20K)	Single nucleotide variant (5 prime UTR variant +2 more)	not provided +2 more	GUncertain significance
Select item 1070997	NM_002439.5(MSH3):c.76C>T (p.Arg26Ter)	DHFR, MSH3 (R26*)	Single nucleotide variant (5 prime UTR variant +2 more)	Familial adenomatous polyposis 4 +3 more	GPathogenic/Likely pathogenic
Select item 2676773	NM_002439.5(MSH3):c.96delinsCT (p.Gly32_Ser33insTer)	DHFR, MSH3	Indel (5 prime UTR variant +2 more)	Endometrial carcinoma	GLikely pathogenic
Select item 861045	NM_002439.5(MSH3):c.97A>G (p.Ser33Gly)	MSH3, DHFR (S33G)	Single nucleotide variant (5 prime UTR variant +2 more)	Familial adenomatous polyposis 4 +3 more	GUncertain significance
Select item 940238	NM_002439.5(MSH3):c.98G>A (p.Ser33Asn)	DHFR, MSH3 (S33N)	Single nucleotide variant (5 prime UTR variant +2 more)	not provided +2 more	GUncertain significance
Select item 651387	NM_002439.5(MSH3):c.112TCC[2] (p.Ser40del)	DHFR, MSH3 (S40del)	Microsatellite (5 prime UTR variant +2 more)	Endometrial carcinoma +2 more	GUncertain significance
Select item 643270	NM_002439.5(MSH3):c.110C>A (p.Thr37Asn)	DHFR, MSH3 (T37N)	Single nucleotide variant (5 prime UTR variant +2 more)	not provided +2 more	GUncertain significance
Select item 1480055	NM_002439.5(MSH3):c.115T>G (p.Ser39Ala)	DHFR, MSH3 (S39A)	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 648547	NM_002439.5(MSH3):c.115T>A (p.Ser39Thr)	DHFR, MSH3 (S39T)	Single nucleotide variant (5 prime UTR variant +2 more)	Familial adenomatous polyposis 4 +3 more	GUncertain significance
Select item 650057	NM_002439.5(MSH3):c.122C>T (p.Thr41Ile)	MSH3, DHFR (T41I)	Single nucleotide variant (5 prime UTR variant +2 more)	Endometrial carcinoma +3 more	GUncertain significance
Select item 1415892	NM_002439.5(MSH3):c.131_138del (p.Ala44fs)	DHFR, MSH3 (A44fs)	Deletion (5 prime UTR variant +2 more)	Endometrial carcinoma +2 more	GPathogenic/Likely pathogenic
Select item 1075635	NM_002439.5(MSH3):c.136C>T (p.Gln46Ter)	DHFR, MSH3 (Q46*)	Single nucleotide variant (5 prime UTR variant +2 more)	not provided +2 more	GPathogenic/Likely pathogenic
Select item 1503166	NM_002439.5(MSH3):c.138G>C (p.Gln46His)	DHFR, MSH3 (Q46H)	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 639800	NM_002439.5(MSH3):c.143A>C (p.Asp48Ala)	DHFR, MSH3 (D48A)	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 648581	NM_002439.5(MSH3):c.146del (p.Pro49fs)	DHFR, MSH3 (P49fs)	Deletion (5 prime UTR variant +2 more)	Endometrial carcinoma +2 more	GPathogenic/Likely pathogenic
Select item 651887	NM_002439.5(MSH3):c.145C>T (p.Pro49Ser)	DHFR, MSH3 (P49S)	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 2676757	NM_002439.5(MSH3):c.152C>G (p.Ala51Gly)	DHFR, MSH3 (A51G)	Single nucleotide variant (5 prime UTR variant +2 more)	Endometrial carcinoma	GUncertain significance
Select item 2676780	NM_002439.5(MSH3):c.161del (p.Ala54fs)	MSH3, DHFR (A54fs)	Deletion (5 prime UTR variant +2 more)	Endometrial carcinoma	GLikely pathogenic
Select item 2676781	NM_002439.5(MSH3):c.169_196del (p.Ala57fs)	DHFR, MSH3 (A57fs)	Deletion (5 prime UTR variant +2 more)	Endometrial carcinoma	GLikely pathogenic
Select item 1780742	NM_002439.5(MSH3):c.181G>A (p.Ala61Thr)	DHFR, MSH3 (A61T)	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 2676748	NM_002439.5(MSH3):c.200dup (p.Ala68fs)	DHFR, MSH3 (A68fs)	Duplication (5 prime UTR variant +2 more)	Endometrial carcinoma	GLikely pathogenic
Select item 2676741	NM_002439.5(MSH3):c.196C>A (p.Pro66Thr)	DHFR, MSH3 (P66T)	Single nucleotide variant (5 prime UTR variant +2 more)	Endometrial carcinoma	GUncertain significance
Select item 1783585	NM_002439.5(MSH3):c.196C>T (p.Pro66Ser)	DHFR, MSH3 (P66S)	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 1692666	NM_002439.5(MSH3):c.196C>G (p.Pro66Ala)	DHFR, MSH3 (P66A)	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 1783782	NM_002439.5(MSH3):c.197C>T (p.Pro66Leu)	DHFR, MSH3 (P66L)	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome +1 more	GUncertain significance
Select item 960339	NM_002439.5(MSH3):c.200C>G (p.Pro67Arg)	DHFR, MSH3 (P67R)	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 2676772	NM_002439.5(MSH3):c.202G>A (p.Ala68Thr)	DHFR, MSH3 (A68T)	Single nucleotide variant (5 prime UTR variant +2 more)	Endometrial carcinoma	GUncertain significance
Select item 944557	NM_002439.5(MSH3):c.211_230dup (p.His78fs)	DHFR, MSH3 (H78fs)	Duplication (5 prime UTR variant +2 more)	not provided +2 more	GPathogenic/Likely pathogenic
Select item 1786872	NM_002439.5(MSH3):c.215del (p.Pro72fs)	DHFR, MSH3 (P72fs)	Deletion (5 prime UTR variant +2 more)	Endometrial carcinoma +1 more	GPathogenic/Likely pathogenic
Select item 1786716	NM_002439.5(MSH3):c.214C>T (p.Pro72Ser)	DHFR, MSH3 (P72S)	Single nucleotide variant (5 prime UTR variant +2 more)	not provided +3 more	GUncertain significance
Select item 1787741	NM_002439.5(MSH3):c.220C>T (p.Gln74Ter)	DHFR, MSH3 (Q74*)	Single nucleotide variant (5 prime UTR variant +2 more)	Endometrial carcinoma +1 more	GPathogenic/Likely pathogenic
Select item 849773	NM_002439.5(MSH3):c.222G>C (p.Gln74His)	DHFR, MSH3 (Q74H)	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 656208	NM_002439.5(MSH3):c.227CGC[3] (p.Pro77dup)	DHFR, MSH3	Microsatellite (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 649836	NM_002439.5(MSH3):c.230C>T (p.Pro77Leu)	DHFR, MSH3 (P77L)	Single nucleotide variant (5 prime UTR variant +2 more)	Endometrial carcinoma +2 more	GUncertain significance
Select item 849780	NM_002439.5(MSH3):c.237+2T>C	MSH3, DHFR	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome +2 more	GPathogenic/Likely pathogenic
Select item 663318	NM_002439.5(MSH3):c.237+3A>G	DHFR, MSH3	Single nucleotide variant (5 prime UTR variant +2 more)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 657647	NM_002439.5(MSH3):c.237+6T>G	DHFR, MSH3	Single nucleotide variant (5 prime UTR variant +2 more)	not provided +1 more	GUncertain significance
Select item 942105	NM_002439.5(MSH3):c.238-1G>A	MSH3	Single nucleotide variant (splice acceptor variant)	Familial adenomatous polyposis 4 +3 more	GLikely pathogenic
Select item 1070750	NM_002439.5(MSH3):c.242del (p.Thr81fs)	MSH3 (T81fs)	Deletion (frameshift variant)	Endometrial carcinoma +3 more	GPathogenic/Likely pathogenic
Select item 2676785	NM_002439.5(MSH3):c.247del (p.Ile83fs)	MSH3 (I83fs)	Deletion (frameshift variant)	Endometrial carcinoma	GLikely pathogenic
Select item 950990	NM_002439.5(MSH3):c.253A>T (p.Arg85Ter)	MSH3 (R85*)	Single nucleotide variant (nonsense)	Hereditary cancer-predisposing syndrome +3 more	GPathogenic/Likely pathogenic
Select item 864272	NM_002439.5(MSH3):c.260_263del (p.Lys87fs)	MSH3 (K87fs)	Microsatellite (frameshift variant)	not provided +3 more	GPathogenic/Likely pathogenic
Select item 1071210	NM_002439.5(MSH3):c.263_267del (p.Lys88fs)	MSH3 (K88fs)	Deletion (frameshift variant)	Hereditary cancer-predisposing syndrome +3 more	GPathogenic/Likely pathogenic
Select item 641817	NM_002439.5(MSH3):c.282T>A (p.Asp94Glu)	MSH3 (D94E)	Single nucleotide variant (missense variant)	not provided +2 more	GUncertain significance
Select item 650967	NM_002439.5(MSH3):c.287C>T (p.Pro96Leu)	MSH3 (P96L)	Single nucleotide variant (missense variant)	Endometrial carcinoma +4 more	GUncertain significance
Select item 822397	NM_002439.5(MSH3):c.296dup (p.Lys100fs)	MSH3 (K100fs)	Duplication (frameshift variant)	Endometrial carcinoma +3 more	GPathogenic/Likely pathogenic
Select item 961118	NM_002439.5(MSH3):c.292A>T (p.Lys98Ter)	MSH3 (K98*)	Single nucleotide variant (nonsense)	Hereditary cancer-predisposing syndrome +2 more	GPathogenic/Likely pathogenic
Select item 644426	NM_002439.5(MSH3):c.298A>G (p.Lys100Glu)	MSH3 (K100E)	Single nucleotide variant (missense variant)	Endometrial carcinoma +2 more	GUncertain significance
Select item 822791	NM_002439.5(MSH3):c.307_310del (p.Lys103fs)	MSH3 (K103fs)	Microsatellite (frameshift variant)	Endometrial carcinoma +2 more	GPathogenic/Likely pathogenic
Select item 1727343	NM_002439.5(MSH3):c.307A>C (p.Lys103Gln)	MSH3 (K103Q)	Single nucleotide variant (missense variant)	Endometrial carcinoma +1 more	GUncertain significance
Select item 652570	NM_002439.5(MSH3):c.316C>T (p.Gln106Ter)	MSH3 (Q106*)	Single nucleotide variant (nonsense)	Hereditary cancer-predisposing syndrome +3 more	GPathogenic/Likely pathogenic
Select item 653785	NM_002439.5(MSH3):c.331_333del (p.Ser111del)	MSH3 (S111del)	Deletion (inframe_deletion)	Endometrial carcinoma +2 more	GUncertain significance
Select item 659546	NM_002439.5(MSH3):c.334G>A (p.Asp112Asn)	MSH3 (D112N)	Single nucleotide variant (missense variant)	not provided +2 more	GUncertain significance
Select item 649417	NM_002439.5(MSH3):c.353A>T (p.Asn118Ile)	MSH3 (N118I)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 658860	NM_002439.5(MSH3):c.358+2T>G	MSH3	Single nucleotide variant (splice donor variant)	Hereditary cancer-predisposing syndrome +3 more	GLikely pathogenic
Select item 643079	NM_002439.5(MSH3):c.379A>G (p.Thr127Ala)	MSH3 (T127A)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 1386968	NM_002439.5(MSH3):c.392del (p.Val130_Ser131insTer)	MSH3	Deletion (nonsense)	Endometrial carcinoma +2 more	GPathogenic/Likely pathogenic
Select item 2099497	NM_002439.5(MSH3):c.408del (p.Lys136fs)	MSH3 (K136fs)	Deletion (frameshift variant)	not provided +2 more	GPathogenic/Likely pathogenic
Select item 662768	NM_002439.5(MSH3):c.421T>C (p.Cys141Arg)	MSH3 (C141R)	Single nucleotide variant (missense variant)	Endometrial carcinoma +2 more	GUncertain significance
Select item 838544	NM_002439.5(MSH3):c.427G>A (p.Asp143Asn)	MSH3 (D143N)	Single nucleotide variant (missense variant)	Endometrial carcinoma +4 more	GConflicting classifications of pathogenicity
Select item 662540	NM_002439.5(MSH3):c.439C>T (p.Pro147Ser)	MSH3 (P147S)	Single nucleotide variant (missense variant)	not provided +2 more	GConflicting classifications of pathogenicity
Select item 2676778	NM_002439.5(MSH3):c.466_467dup (p.Gln157fs)	MSH3 (Q157fs)	Microsatellite (frameshift variant)	Endometrial carcinoma	GLikely pathogenic
Select item 825207	NM_002439.5(MSH3):c.481G>A (p.Ala161Thr)	MSH3 (A161T)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 2676737	NM_002439.5(MSH3):c.488T>G (p.Leu163Arg)	MSH3 (L163R)	Single nucleotide variant (missense variant)	Endometrial carcinoma +1 more	GUncertain significance
Select item 652371	NM_002439.5(MSH3):c.534G>T (p.Lys178Asn)	MSH3 (K178N)	Single nucleotide variant (missense variant)	Endometrial carcinoma +2 more	GUncertain significance
Select item 644519	NM_002439.5(MSH3):c.554A>G (p.Asp185Gly)	MSH3 (D185G)	Single nucleotide variant (missense variant)	Endometrial carcinoma +2 more	GUncertain significance
Select item 639536	NM_002439.5(MSH3):c.562C>T (p.Arg188Cys)	MSH3 (R188C)	Single nucleotide variant (missense variant)	not provided +4 more	GConflicting classifications of pathogenicity
Select item 825881	NM_002439.5(MSH3):c.565C>T (p.Gln189Ter)	MSH3 (Q189*)	Single nucleotide variant (nonsense)	Familial adenomatous polyposis 4 +3 more	GPathogenic/Likely pathogenic
Select item 643818	NM_002439.5(MSH3):c.574C>T (p.Gln192Ter)	MSH3 (Q192*)	Single nucleotide variant (nonsense)	Endometrial carcinoma +3 more	GPathogenic/Likely pathogenic
Select item 1503258	NM_002439.5(MSH3):c.579+1G>A	MSH3	Single nucleotide variant (splice donor variant)	not provided +3 more	GLikely pathogenic
Select item 1513942	NM_002439.5(MSH3):c.580-2A>G	MSH3	Single nucleotide variant (splice acceptor variant)	Hereditary cancer-predisposing syndrome +2 more	GConflicting classifications of pathogenicity
Select item 643370	NM_002439.5(MSH3):c.586del (p.Thr196fs)	MSH3 (T196fs)	Deletion (frameshift variant)	Familial adenomatous polyposis 4 +3 more	GPathogenic/Likely pathogenic
Select item 663256	NM_002439.5(MSH3):c.587C>T (p.Thr196Ile)	MSH3 (T196I)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +2 more	GUncertain significance
Select item 2676733	NM_002439.5(MSH3):c.606G>C (p.Gln202His)	MSH3 (Q202H)	Single nucleotide variant (missense variant)	Endometrial carcinoma	GUncertain significance
Select item 836142	NM_002439.5(MSH3):c.608T>C (p.Phe203Ser)	MSH3 (F203S)	Single nucleotide variant (missense variant)	not provided +1 more	GUncertain significance
Select item 1467975	NM_002439.5(MSH3):c.610G>C (p.Gly204Arg)	MSH3 (G204R)	Single nucleotide variant (missense variant)	Endometrial carcinoma +1 more	GUncertain significance
Select item 644433	NM_002439.5(MSH3):c.653C>T (p.Ser218Phe)	MSH3 (S218F)	Single nucleotide variant (missense variant)	not provided +2 more	GUncertain significance
Select item 2114035	NM_002439.5(MSH3):c.669del (p.Lys223fs)	MSH3 (K223fs)	Deletion (frameshift variant)	not provided +1 more	GPathogenic/Likely pathogenic
Select item 647524	NM_002439.5(MSH3):c.670C>T (p.Arg224Trp)	MSH3 (R224W)	Single nucleotide variant (missense variant)	Endometrial carcinoma +3 more	GUncertain significance
Select item 654492	NM_002439.5(MSH3):c.692C>T (p.Pro231Leu)	MSH3 (P231L)	Single nucleotide variant (missense variant)	Hereditary cancer-predisposing syndrome +3 more	GUncertain significance
Select item 837189	NM_002439.5(MSH3):c.703C>T (p.Gln235Ter)	MSH3 (Q235*)	Single nucleotide variant (nonsense)	Hereditary cancer-predisposing syndrome +3 more	GPathogenic/Likely pathogenic
Select item 2676755	NM_002439.5(MSH3):c.719A>G (p.Lys240Arg)	MSH3 (K240R)	Single nucleotide variant (missense variant)	Endometrial carcinoma	GUncertain significance
Select item 1068925	NM_002439.5(MSH3):c.724C>T (p.Gln242Ter)	MSH3 (Q242*)	Single nucleotide variant (nonsense)	not provided +3 more	GPathogenic/Likely pathogenic
Select item 1758142	NM_002439.5(MSH3):c.729C>A (p.His243Gln)	MSH3 (H243Q)	Single nucleotide variant (missense variant)	Endometrial carcinoma +2 more	GConflicting classifications of pathogenicity
Select item 642746	NM_002439.5(MSH3):c.733G>A (p.Asp245Asn)	MSH3 (D245N)	Single nucleotide variant (missense variant)	not provided +2 more	GUncertain significance
Select item 662932	NM_002439.5(MSH3):c.758G>C (p.Gly253Ala)	MSH3 (G253A)	Single nucleotide variant (missense variant)	MSH3-related condition +3 more	GUncertain significance
Select item 841131	NM_002439.5(MSH3):c.790G>T (p.Glu264Ter)	MSH3 (E264*)	Single nucleotide variant (nonsense)	not provided +3 more	GPathogenic/Likely pathogenic
Select item 652518	NM_002439.5(MSH3):c.802C>T (p.Arg268Ter)	MSH3 (R268*)	Single nucleotide variant (nonsense)	Hereditary cancer-predisposing syndrome +3 more	GPathogenic/Likely pathogenic
Select item 859952	NM_002439.5(MSH3):c.803G>A (p.Arg268Gln)	MSH3 (R268Q)	Single nucleotide variant (missense variant)	not provided +2 more	GUncertain significance
Select item 655983	NM_002439.5(MSH3):c.808C>T (p.Leu270Phe)	MSH3 (L270F)	Single nucleotide variant (missense variant)	not provided +2 more	GUncertain significance
Select item 650171	NM_002439.5(MSH3):c.824A>G (p.His275Arg)	MSH3 (H275R)	Single nucleotide variant (missense variant)	Endometrial carcinoma +2 more	GUncertain significance

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